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Author

Yee Hwee Lim

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Open access Oct 2026

An activator-free method for the synthesis of nucleotide 5′–5′ triphosphate mRNA capping agent

The traditional synthesis of nucleotide 5′–5′ triphosphate linkages involves a “2 + 1” phosphate coupling mediated by a large excess of metal salts, where the salt removal is a labor and waste-intensive step. We have omitted the metal salts from this reaction by modulating the solubility and reactivity of the monophosp...

Eric Tam, Viktor Barát, T. Y. Saw et al. · 0 citations
Oct 2026

An Integrated Computational-Experimental Workflow for Fungal Peroxygenase Discovery and Enzyme–Substrate Prediction

Recent advances in enzyme informatics have produced increasingly powerful general models for the prediction of protein function prediction. However, their performance remains limited for underexplored enzyme families where experimental data are scarce and heterologous expression remains challenging. Here, we present...

V. J. Lim, Yee-Song Law, G. Peh et al. · 0 citations
Jul 2026

High‐Throughput Screening of Flavan‐3‐Ol Antioxidants Through DFT ‐Guided Machine Learning

An integrated computational strategy that combines density functional theory with graph neural network‐based machine learning to predict three key thermodynamic descriptors governing antioxidant reactivity is introduced, confirming that aromatic hydroxylation enhances predicted reactivity and that the energetic orderin...

Z. Wong, Ying-Sin Koo, Yee Hwee Lim et al. · 0 citations

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