The traditional synthesis of nucleotide 5′–5′ triphosphate linkages involves a “2 + 1” phosphate coupling mediated by a large excess of metal salts, where the salt removal is a labor and waste-intensive step. We have omitted the metal salts from this reaction by modulating the solubility and reactivity of the monophosp...
Eric Tam, Viktor Barát, T. Y. Saw et al.· RSC Advances· 0 citations
Recent advances in enzyme informatics have produced increasingly powerful general models for the prediction of protein function prediction. However, their performance remains limited for underexplored enzyme families where experimental data are scarce and heterologous expression remains challenging. Here, we present...
V. J. Lim, Yee-Song Law, G. Peh et al.· Journal of Chemical Informat...· 0 citations
An integrated computational strategy that combines density functional theory with graph neural network‐based machine learning to predict three key thermodynamic descriptors governing antioxidant reactivity is introduced, confirming that aromatic hydroxylation enhances predicted reactivity and that the energetic orderin...
Z. Wong, Ying-Sin Koo, Yee Hwee Lim et al.· International Journal of Qua...· 0 citations
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