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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

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Ye-Ting Zeng

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Open access Oct 2026

Endogenous APP-Associated Proteomics in Mouse Brain Defines a Candidate Resource for APP Trafficking and Proteostasis Studies

Background/Objectives: Affinity proteomics of amyloid precursor protein (APP) is complicated by proteolytic processing, dynamic trafficking, and purification background. We generated a C-terminal 3×FLAG knock-in at the endogenous App locus to establish a cortical affinity-proteomic resource and prioritize APP-associate...

Ye-Ting Zeng, Shu-Shan Wei, Ke-Yi Hu et al. · 0 citations

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