Osteosarcoma (OS) remains difficult to cure once it becomes metastatic, recurrent, or resistant to chemotherapy, and immune checkpoint blockade has provided limited clinical benefit. The metabolic-immune tumor microenvironment (TME) is one barrier to effective immunity because malignant, stromal, and immune cells compe...
Jia-Wei Yin, Shuai Lu, Yi-Kai Liu et al.· Frontiers in Immunology· 0 citations
Sarcopenia is a disease characterized by reduced muscle mass and strength. In recent years, increasing evidence suggests that gut microbiota (GM) may play an important role in the pathogenesis of sarcopenia. GM is associated with muscle health by affecting muscle metabolism, regulating inflammatory responses, and promo...
Yi-Kai Liu, Shuai Lu, Lei Li et al.· Frontiers in Nutrition· 1 citation
Senile osteoporosis should be viewed as a systemic aging-related disorder involving both deterioration of the local bone microenvironment and whole-body metabolic dysregulation, which may explain why conventional antiresorptive therapies often fail to fully restore the structural and functional deficits of the aging sk...
Ruifeng Bai, Zi-Shuai Huang, Xuan Tian et al.· Frontiers in Aging· 0 citations
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