Author

Yasutoshi Takashima

2 papers indexed here

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Open access Sep 2026

RNF43 p.G659fs leads to natural killer cell dysfunction in MSI-high colorectal cancer through PI3K/AKT/mTOR signaling and HLA-E up-regulation

The RNF43 p.G659fs (RNF43659mut) mutation occurs in 8% of colorectal cancers (CRCs) and is enriched in microsatellite instability–high (MSI-H) tumors. Although RNF43659mut promotes tumor growth through phosphatidylinositol 3-kinase/protein kinase B/mechanistic target of rapamycin (PI3K/AKT/mTOR) activation independent...

Pushpamali De Silva, Samantha Fitzgerald, Jules Cazaubiel et al. · Science Advances · 0 citations

Review Sep 2026

Abstract A091: Single-cell spatial transcriptomics reveals reprograming molecular hallmarks of PanIN initiation and progression preceding histological changes

Recent studies have identified a high prevalence of low grade pancreatic intraepithelial neoplasia (PanIN) in the pancreata of healthy adults. This study aimed to characterize the transcriptomic landscape of human PanINs at single cell resolution, with the goal of identifying hallmarks of initiation and progressi...

C. Nguyen, Anders W. Ohman, Winston R. Becker et al. · Cancer Research · 0 citations