Author

Yaqin Tang

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Review Oct 2026

Nucleoside antitumor drugs: From molecular mechanisms and adaptive resistance to clinical translation.

Nucleoside-based anticancer drugs are still needed to treat solid tumours and blood cancers, but due to systemic toxicity and the emergence of resistance, they have performed poorly in clinical practice. These agents inhibit deoxyribonucleic acid (DNA) synthesis, disrupt ribonucleic acid (RNA) metabolism, or deplete nu...

Chun-Yuan Gan, Jin-Hu Xiang, Yao-Hua Liu et al. · Biochemical Pharmacology · 0 citations

Review Open access Aug 2026

Overcoming hepatic tropism: Precision engineering of lipid nanoparticles for extrahepatic RNA delivery

This review summarizes recent advances in delivery to the lungs, spleen, brain, heart, kidney, bone, and pancreas, discusses major translational bottlenecks, and proposes a direction for predictive design.

Yu Liu, Xiao Guo, Qin Hu et al. · Materials Today Bio · 0 citations

Aug 2026

Cascade-responsive biomimetic nanoparticles remodel tumor metabolism and potentiate ferroptosis for synergistic therapy of aggressive breast cancer.

In vitro and in vivo evaluations confirm that R-A/G@Z effectively suppresses aggressive breast tumors while maintaining a good safety profile, offering a promising strategy for intelligent metabolic-chemodynamic cancer nanomedicine.

Nian-Ting Xiao, Xiao He, Da-Xiu Li et al. · Journal of Colloid and Inter... · 0 citations