Symmetry analysis and ancestral sequence reconstruction reveal a symmetrical translocation pathway and activity determinants of ZIP metal transporters.
Membrane transporters frequently exhibit internal structural symmetry, reflecting evolutionary origins through gene duplication and fusion events, and this feature has been widely used to infer transport mechanisms. Yet its application to the Zrt-/Irt-like protein (ZIP) family of divalent metal transporters, which are...
Yao Zhang, Tian-Qi Wang, Hong-Yan Zhao et al.
· Protein Science · 0 citations