Author

Yao Wei

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Open access Jul 2026

ThermoFusion: A Multimodal Deep Learning Framework for Generalizable Prediction of Enzyme Thermostability

ThermoFusion, a hybrid deep learning framework that integrates 3D protein structure embeddings from ThermoMPNN with sequence-based embeddings from the pretrained protein language model ESM2 to predict the effects of single-point mutations on protein stability is presented.

Yao Wei, I. Eberini, Fabian Meyer · bioRxiv · 0 citations