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Author

Yao Wang

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Open access Oct 2026

TRIM2 negatively regulates antiviral immunity by degradation of MDA5 and STAT2 during influenza A virus infection

This study identifies TRIM2 as an interferon-stimulated gene (ISG) regulated by both type I and type II interferons. Contrary to the typical antiviral role of most ISGs, TRIM2 significantly enhances influenza A virus (IAV) replication both in vitro and in vivo. Mechanistically, TRIM2 functions as a negative regulator...

Yu-Ying Zhang, Hao-Ning Li, Yao Wang et al. · 0 citations
Review Open access Aug 2026

Microglial Dual Nature in Maintaining Spatiotemporal Homeostasis

This review synthesizes current understanding of how developmental programming, regional specialization, temporal regulation, and metabolic adaptation collectively shape dynamic microglial states across health and disease and discusses emerging therapeutic strategies aimed at context-dependent modulation of microglial...

Shun-Qi Wang, Yao Wang, Chun-Yang Hou et al. · 0 citations

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