Author

Yao Nie

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Aug 2026

Characterization of a neral reductase from Serratia marcescens: Structure-guided engineering and construction of an efficient whole-cell cascade for (S)-citronellol synthesis.

In this study, a previously uncharacterized neral reductase (an ene-reductase), SmNR (Serratia marcescens Neral Reductase), belonging to the Old Yellow Enzyme family, was identified and functionally characterized from Serratia marcescens HBQA7. SmNR efficiently catalyzes the asymmetric reduction of neral to produce (S)...

Rui-Shi Xie, Long Wang, Sheng-Fang Wu et al. · International Journal of Bio... · 0 citations

Sep 2026

Engineering an F-Amine Dehydrogenase for Efficient and Sustainable Biocatalytic Synthesis of a Chiral PDE10 Inhibitor Precursor

(R)–4-(1H-indol-3-yl)butan-2-amine ((R)-4IBA), encompassing a nitrogen heterocycle and a chiral primary amino group, is a highly appealing precursor in the pharmaceutical domain. The direct amination of the readily available prochiral ketone 4-(1H-indol-3-yl)butan-2-one (4IBO) catalyzed by amine dehydrogenases (AmDHs...

Tao Wu, Yi-Fei Gong, Yao Nie et al. · ACS Sustainable Chemistry &a... · 0 citations

Review Aug 2026

Harnessing Machine Learning for Enzyme Enantioselectivity: Toward Intelligent Biocatalysis Engineering

This review systematically evaluates how machine learning integrates multimodal datasets, including sequence, structural, and functional performance data, to advance the discovery and engineering of naturally enantioselective enzymes, and enable the de novo design of artificial enzymes for reaction-relevant application...

Jie Gu, Yan Xu, Xiao-Yan Sun et al. · ACS Synthetic Biology · 0 citations