Open access
Sep 2026
SPINT2 Is Associated with Dual-Phenotype Hepatocellular Carcinoma and Aggressive Tumor Features
Background: Hepatocellular carcinoma (HCC) heterogeneity, particularly the presence of tumor cells co-expressing hepatocytic and cholangiocytic markers, contributes to therapeutic resistance and poor prognosis, yet its molecular correlates remain incompletely understood. This study aimed to characterize dual-phenotype...
Jie Zhang, Min-Jun Li, Tai-Xin Yang et al.
· Cancers · 0 citations