Yanyan Li

DeepCRISPR-Typer: Accurate CRISPR-Cas Identification and Subtyping in Metagenomes via Integrated Deep Learning

DeepCRISPR-Typer is presented, a comprehensive computational framework integrating a large protein language model (TEMC-Cas), a deep sequence feature extractor (CRISPR-RepTyper), and an adaptive targeted HMM profiling strategy that significantly reduces computational overhead by dynamically invoking subtype-specific HMM subsets.