Author

Yanqing Liu

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Open access Aug 2026

Discovery of a Potent and Selective KRAS G12D Degrader based on PROTAC Degradation.

This work designed and synthesized 20 novel KRAS G12D PROTACs based on the MRTX1133 derivative and found that compound VI-1 exhibited significant KRAS G12D degradation activity in PANC-0203 cells, achieving 69% effective degradation at 10 μM.

Lili Jiang, Wenyan Yang, Yanqing Liu et al. · European Journal of Pharmace... · 0 citations

Open access Jul 2026

Discovery of Novel AURKA Inhibitors for Triple-Negative Breast Cancer (TNBC) Therapy via a Hybrid Virtual Screening Pipeline, Biological Evaluation and Molecular Dynamics Simulation

A cascaded AI-driven virtual screening pipeline is developed, integrating sequence-based affinity prediction, equivariant deep learning docking (KarmaDock), and geometric rescoring (DeepDock) to identify novel AURKA inhibitor candidates.

Pei Liu, Yanqing Liu, Xin Zhang et al. · ACS Omega · 0 citations