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Yanhong Chu

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Open access Sep 2026

A bio-orthogonally engineered probiotic-T cell chimera amplifies adoptive cell therapy through spatial DC-T cell immune licensing.

Mechanistically, T-FOLactis promoted dendritic cell (DC)-T cell proximity and established a spatially organized immune-licensing niche that amplified the functional impact of FOLactis-induced inflammatory cues, including IL-18, establishing a modular cell-surface engineering strategy for augmenting ACT in colorectal ca...

Jing-Wen Shen, Yanhong Chu, Yan Wang et al. · 0 citations

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