Author

Yang Zhou

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Sep 2026

Design, Synthesis, and Antimicrobial Activity of Novel Cyt- bd Inhibitors Targeting Energy Compensation in Mycobacterium tuberculosis

Drug-resistant Mycobacterium tuberculosis (Mtb) poses a growing threat, necessitating new therapeutic strategies. The cytochrome bcc-aa3 oxidase (Cyt-bcc) is an attractive target, yet single-agent inhibition fails owing to compensation by the alternative cytochrome bd terminal oxidase (Cyt-bd). Herein, we describe a...

Qiao Qin, Zhuo-Heng Liu, Chen-Yi Cheung et al. · ACS Medicinal Chemistry Lett... · 0 citations

#quantum computing Open access Nov 2025

Macrocycle-DB: a comprehensive database for macrocycle-based drug discovery

Macrocycle-DB is presented, the most extensive online database dedicated to macrocycles, featuring 45 525 compounds, including 76 approved drugs and 105 clinical candidates that target 2533 proteins.

Minchuan Jiang, Tianyu Liu, Muzammal Hussain et al. · Nucleic Acids Research · 6 citations