Oct 2026
A gut microbial odd-chain fatty acid alleviates atherosclerosis in mice.
Chao Yin, You-Zhe Chen, Gan Lin et al.
· Nature · 1 citation
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Open access
Oct 2026
Inhibition of the NR4A1-mediated cell cycle checkpoint enhances hyperplastic adipogenesis and glucose homeostasis in obesity.
BACKGROUND AND PURPOSE The nuclear receptor NR4A1 is a critical node in transcriptional circuits for metabolic adaptation, yet its role in adipocyte progenitor (AP) fate and proliferation is unclear. We sought to define how NR4A1 governs early adipogenesis and adipose tissue plasticity. EXPERIMENTAL APPROACH Doxycycl...
Wan-Ning Qiao, Cun Ku, G. V. Naveen Kumar et al.
· British Journal of Pharmacol... · 0 citations
Open access
Jul 2026
A Hierarchical Multimodal Knowledge Graph for Neural Cell-Type-Specific Regulation Integrating Single-Cell Transcriptomics and Literature Evidence
A neural-cell-centric multimodal knowledge graph that transforms fragmented regulatory evidence into a standardized, computable substrate and provides a structured basis for cross-study comparison, hypothesis generation and knowledge-guided reasoning in neural cell-type-specific regulation.
Chuangyu Chen, Xiaomin Ni, Yang Min et al.
· International Journal of Mol... · 0 citations