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Author

Yang Yang

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Open access Sep 2026

Immune heterogeneity-driven therapeutic responses to platelet-rich plasma and TRPV1 antagonism in osteoarthritis

Introduction Osteoarthritis (OA) exhibits substantial heterogeneity in synovial immune profiles, which may underlie variable analgesic responses to standard biological and neuromodulatory treatments. Remodeling the immune microenvironment while targeting nociceptive pathways may improve therapeutic consistency. Methods...

Peng Liu, Jing-Wei Zhu, Yang Yang et al. · 0 citations
Jul 2026

Lactate-associated H3K18 lactylation is involved in IGF2BP2-mediated MARCKSL1 mRNA stabilization and inflammatory signaling in LPS-induced acute lung injury.

The findings decipher a novel H3K18la/IGF2BP2/MARCKSL1 signaling cascade that integrates metabolic reprogramming with m6A epitranscriptomics in ALI, highlighting IGF2BP2 as a promising target for preventive intervention in airway epithelial inflammation.

Yangdi Peng, Jun-Yao Zhang, Yang Yang et al. · 0 citations

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