Author

Yangwa Wei

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Open access Aug 2026

lncRNA TUG1 mediates palmitic acid-induced neuronal lipotoxic injury via the miR-449a-5p/caspase-3 and Akt/GSK-3β axes

Findings establish a causal axis in which lncRNA TUG1 derepresses caspase-3 and suppresses Akt/GSK-3β signaling by sponging miR-449a-5p, thereby driving neuronal lipotoxic injury.

Yang-Wa Wei, Peng-Yao Chen, Xin Zheng et al. · International Journal of Mol... · 0 citations

Review Aug 2026

Mitochondrial Dysfunction in Neurodegenerative Diseases: Mechanisms and Therapeutic Advances.

It is demonstrated that mitochondrial impairment precedes classical neuropathological hallmarks, thereby positioning mitochondrial dysfunction as a primary driver rather than a secondary consequence of neurodegeneration, and critically evaluates the translational landscape of mitochondria-targeted interventions.

Zhaomin Yao, Yang-Wa Wei, Weiming Xie et al. · Ageing Research Reviews · 0 citations