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Author

Yang Shi

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Open access Oct 2026

H3K27M cooperates with ASCL1 to maintain progenitor states and drive gliomagenesis

Histone 3 lysine 27-to-methionine substitutions (H3K27M) drive aggressive diffuse midline gliomas by blocking differentiation of radial glial progenitor cells committed to oligodendrogenesis. We establish prolonged differentiation as a powerful tool to uncover regulators of glioma cell states and demonstrate that t...

Alan L. Jiao, Abolfazl Maghrouni, A. Gutiérrez et al. · 0 citations
Open access Sep 2026

Thymic age and peripheral residence time determine antitumor competence of CD8+ T cells.

These findings establish developmental imprinting as an important determinant of CD8+ T cell heterogeneity and identify CXCR3+IL-18Rα+ CD8+ T cells as key effectors for antitumor immunity.

Yuan-Qin Yang, Yun-Yi Wang, Amanda Wicki et al. · 0 citations

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