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Sep 2026

Metabolic-epigenetic reprogramming of airway fibroblasts by K + N therapy suppresses IL-33 and ameliorates allergic asthma.

BACKGROUND Allergic asthma is a prevalent Th2-driven chronic inflammatory airway disease. While lung fibroblasts and fibroblast-derived IL-33 critically regulate airway inflammation, the fibroblast-specific role of IL-33 and the therapeutic mechanism of the immune regulatory small-molecule KQS1 and nicotinamide (K + N)...

Xiang-Dong Sun, Yuan-Yi Zhang, Ya-Dong Zheng et al. · 0 citations
Open access Aug 2026

Multi-Omic Analysis of Putative Cellular Senescence-Associated Genes on the Risk of Pan-Cancer.

Cellular senescence plays a critical role in physiological and pathological processes. This study aims to elucidate the contribution of cellular senescence-related genes to disease etiology. We investigated a cohort study of 439,501 individuals, which included 22 cancers and 9 non-cancer diseases. We found that HLA-E a...

Bin Liu, Wei-Dong Wu, Chang Liu et al. · 0 citations

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