Author

Yang Meng

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Review Aug 2026

Beyond senescence entry: individual-cell fates, population outcomes and therapeutic implications in ageing and disease.

Cellular senescence is a stress-response program characterized by durable proliferative arrest, but senescence entry does not determine a single biological outcome. Confusion between the fate of an individual cell and the behavior of a senescent-cell population has obscured interpretation across development, ageing and...

Guosong Wang, Yang Meng, Jun-Hong Han · Ageing Research Reviews · 0 citations

Review Open access Aug 2026

Histone modifications: mechanisms, metabolic regulation, and therapeutic targeting in cancer

This review comprehensively summarizes the multifaceted roles of major histone modifications, including acetylation, methylation, ubiquitination, phosphorylation, and emerging metabolism-linked acylations, in governing critical DNA-templated processes such as replication, transcription, and the DNA damage response.

Ling-Li Wang, Shi-Ying Li, Xiao-Yan Hu et al. · Precision Clinical Medicine · 1 citation

Open access Jul 2026

Targeting HASPIN-mediated H3T3 phosphorylation disrupts an epigenetic-kinesin axis to suppress colorectal cancer mitotic progression.

The findings identify the HASPIN/H3T3ph-KDM5B-H3K4me3-KIF axis as a targetable antimitotic pathway and support therapeutic inhibition of HASPIN/H3T3ph as a potential strategy for CRC.

Tong Wu, Yaguang Zhang, Si-Cheng Liu et al. · Molecular Cancer · 0 citations