Review
Open access
Oct 2026
Targeting TEAD in cancers: paralog-specific biology, resistance and therapeutic opportunities
The TEA domain transcription factors TEAD1 to TEAD4 integrate Hippo signaling with transcriptional programs that govern tissue homeostasis and cancer progression. Their activity is shaped by cofactor engagement, palmitoylation, chromatin organization and extracellular cues, creating therapeutic vulnerabilities that v...
Jia-Lin Wu, Fu-Da Xie, Bo-Nan Chen et al.
· Molecular Cancer · 0 citations