Sep 2026
MMSDH facilitates ACSL4 propionylation to counteract ferroptosis upon hypoxia and impairs PDAC chemotherapy efficacy.
Pei-Xiang Zheng, Yan-Ni Lin, Mei-Yin Zhang et al.
· Nature Cancer · 0 citations
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Open access
Aug 2026
Neutrophil Senescence Induced by Tumor-Derived HMGB1 Promotes Hepatocellular Carcinoma Progression through Neutrophil Extracellular Trap-Mediated Suppression of CD8+ T Cell Immunity
Background: Immune cells are essential components of the tumor microenvironment. Among them, neutrophils have gained increasing interest due to their marked heterogeneity. This study focused on aged neutrophils, aiming to uncover their mechanistic contribution to hepatocellular carcinoma (HCC) progression and evaluate...
Ya-Qian Duan, Shan Yu, Xuan Wang et al.
· Cancer Communications · 0 citations
Review
Open access
Aug 2026
Human biomarker navigator
This review offers the initial comprehensive elucidation of the biomarker interaction networks across diverse systems, organs, and diseases, and delineates the operational framework for establishing a “biomarker navigation system”.
Meng-Yao Li, Qian Zhang, Zi-Jie Wang et al.
· iMeta · 2 citations
Review
Open access
Jul 2026
Tumor heterogeneity: development, mechanisms, and therapeutic implications
This review synthesizes key advances in understanding tumor heterogeneity: from its cellular origins and molecular mechanisms to its multidimensional manifestation in the tumor microenvironment and from metastatic heterogeneity to the fundamental causes of treatment resistance.
Jianhong Zhang, Heng Li, S. Ru et al.
· Signal Transduction and Targ... · 1 citation