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Oct 2026

Discovery of novel CDK9 inhibitors containing 1H-pyrrolo[2,3-b]pyridine moiety for treatment of colorectal cancer.

Mechanistic studies and in vivo experiments demonstrated that intravenous injection of compound B3 could achieve prominent therapeutic efficacy with a high safety profile and indicate that compound B3 is a promising candidate for CRC treatment.

Ye Zhong, Jing Xu, Lian-Zhe Zhang et al. · 0 citations
Aug 2026

Discovery of novel quinazoline-containing ATR inhibitor for treatment of acute myeloid leukemia.

ATR is a core kinase in the DNA damage response pathway, primarily sensing replication pressure and double strand breaks, initiating cell cycle arrest, DNA repair, and apoptosis programs, and maintaining genomic stability. In this work, we validated that intervention in ATR function might regulate the progression of AM...

Xia-Yu Li, Jia-Yu Zhang, Jia-Yu Hao et al. · 0 citations

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