Author

Yang Liu

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Open access Jul 2026

Continuous target-specific mutagenesis and rapid gene evolution by diversity-generating retroelements in Escherichia coli

DGRs can be installed in E. coli and reprogrammed for the continuous, iterative mutagenesis of user-defined target genes, and the DGR template RNA can be reprogrammed for gene- and residue-specific mutagenesis, leaving untargeted, adjacent residues unchanged.

Yang Liu, Yang-Qi Gu, Ganesh Agam et al. · bioRxiv · 0 citations