Author

Yang Liu

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Open access Sep 2026

Identification of CD40 as the target of artemisinin via targeted degradomics for ulcerative colitis.

Current drugs for ulcerative colitis often face challenges such as significant side effects, high costs, and tendency to induce drug resistance. Repurposing existing drugs is a promising approach that builds on their known safety and efficacy profiles. Artemisinin (Art), a first-line antimalarial agent, shows anti-infl...

Zhi-Qi Zhang, Hao-Ze Song, Yi-Xing Li et al. · Bioorganic chemistry (Print) · 0 citations

Open access Sep 2026

PROTAC probe-assisted degradomics identifies SPINT2 as a candidate cellular target involved in the anti-cancer activity of Flupentixol.

Targeted protein degradation has emerged not only as a therapeutic modality but also as a useful strategy for target deconvolution. This study investigated the anti-cancer activity and pharmacological targets of the anti-psychotic drug Flupentixol using a PROTAC probe-assisted degradomics strategy. We first verified th...

Ming-Yue Lv, Qing-Yuan Hu, Jing-Kai Liang et al. · Bioorganic chemistry (Print) · 0 citations

Aug 2026

Discovery of DCAF16-based PROTACs as SHP2 degraders.

The design and synthesis of SHP2 PROTACs that recruit the DCAF16 E3 ligase for targeted SHP2 degradation are reported that support the potential of SHP2-targeted protein degradation as an alternative strategy to enzymatic inhibition and provide a promising starting point for the further development of SHP2 degraders.

X. Pang, Yuxin Gan, Qing-Yuan Hu et al. · Bioorganic chemistry (Print) · 0 citations