Oct 2026
Usp3 negatively regulates Mda5-mediated antiviral response by attenuating its K63-linked ubiquitination in black carp.
Melanoma differentiation-associated gene 5 (MDA5) is a critical cytosolic RNA sensor that initiates type I interferon (IFN) signaling upon viral infection, and its activity must be tightly regulated to maintain immune homeostasis. Ubiquitin-specific protease 3 (USP3) has been identified as a negative regulator of RLR-m...
Wei Qin, Li-Xia Xie, Hui-Xian Shi et al.
· Fish and Shellfish Immunolog... · 0 citations