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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Yang Hu

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Aug 2026

Targeting PKM2 by (+)-homocrepidine A restrains glycolytic reprogramming and reshapes macrophage fate to alleviate acute lung injury.

HCA is identified as the bioactive enantiomer responsible for the anti-ALI activity of HCA and PKM2-mediated immunometabolic reprogramming underlies its protective effects, establishing PKM2 as a promising therapeutic target and (+)-HCA as a potential lead compound for ALI treatment.

Rong-Rong Dong, Yu Yang, Na Luo et al. · 0 citations
Sep 2026

3-Hydroxydehydroleucodin ameliorates neuroinflammation and ischemic brain injury by blocking the TRIM21-PRDX1 interaction.

3-Hyd is used as a potent neuroprotective agent that markedly reduces the cerebral infarct area and improves neurological deficits in a mouse model of transient middle cerebral artery occlusion and the anti-neuroinflammatory and cerebroprotective effects of 3-Hyd were largely abolished in microglia-specific Prdx1 condi...

Kui Liu, Ling Wang, Zhuo Chen et al. · 0 citations

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