Open access
Aug 2026
CK2α restriction of STING accumulation underlies systemic aging
This work identifies lamin A/C (LMNA) as a critical NE scaffold that orchestrates STING regulation by recruiting both STING and Casein Kinase 2 (CK2α), and establishes the LMNA-CK2-STING axis as a key biochemical mechanism that suppresses innate immune activation at the NE.
Jie Zhang, Mei-Ling Jin, Dan Rao et al.
· Nature Communications · 0 citations