Author

Yan-Xuan Wu

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Review Open access Sep 2026

Neuroimmune crosstalk in osteoarthritis pain: from synovial inflammation to pain sensitization

The synovium is examined as an immune niche in OA pain and follows the signals that connect activated macrophages, fibroblast-like synoviocytes, mast cells, T cells, and damaged chondrocytes with nociceptor sensitization.

Zhong-Yan Mao, Kang Wang, Yan-Xuan Wu et al. · Frontiers in Immunology · 1 citation

Open access Aug 2026

Metabolic Engineering of Komagataella Phaffii for de Novo Synthesis of Retinol From Methanol

Retinol, a derivative of vitamin A with potent antioxidant and therapeutic properties, is in high market demand. In response to the low productivity of conventional methods, metabolic engineering has been explored for microbial retinol production. However, systematic engineering strategies for high‐level retinol synthe...

Yan-Xuan Wu, Chen-Guang Liu, Shu-Li Liang et al. · Biotechnology Journal · 0 citations

Aug 2026

Reprogramming Komagataella phaffii Cell Factory for High-Yield Production of 3S,3′S-Astaxanthin via Multiplex Metabolic Engineering and Its Application

The synthesis of 3S,3′S-astaxanthin was successfully and effectively applied in shrimp farming for color enhancement and antioxidant effects and will pave the way for astaxanthin industrial production.

Xinying Zhang, Ji-Yuan Hu, Yan-Xuan Wu et al. · ACS Synthetic Biology · 0 citations