Mitochondrial DNA (mtDNA) mutations cause multisystem disorders often involving gastrointestinal dysfunction. However, the mechanisms governing the selection against mutant mtDNA and the specific impact of pathogenic mtDNA mutations on intestinal epithelial cells (IECs) remain poorly understood. Here, we employed...
DeepTrack is presented, a lineage tracing mouse model that integrates in situ cellular barcoding with high-throughput, single-cell multi-omics to simultaneously profile clonal fates, transcriptomic states, and chromatin accessibility and provides a versatile framework for decoding multimodal regulation of cell fate acr...
Chen-Yu Guo, Jun-Yao Jiang, Xiao-Min Wang et al.· bioRxiv· 0 citations
It is suggested that CTCF contributes to the coordinated regulation of chromatin organization and transcriptional capacity and is associated with stabilization of long-range active chromatin clusters.
Zi-Yin Chen, Xuan-Yu Li, Yun-Peng Dai et al.· Science Advances· 0 citations
A comprehensive transcriptomic and chromatin accessibility atlas of 8 brain regions of 23 female cynomolgus macaques spanning the adult lifespan, including exceptionally old individuals establishes a foundational framework for understanding the cellular and regulatory architecture of primate brain aging and its links t...
