Author

Yan Wang

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Open access Oct 2026

Pan-cancer and experimental analyses reveal TTC39B as a suppressor of cell proliferation in clear cell renal cell carcinoma

Tetratricopeptide repeat domain protein 39B (TTC39B) is a lipid metabolism–related gene recently implicated in cholesterol regulation. However, its clinical and biological relevance in human cancers remains undefined. Based on multi-omics data from the Cancer Genome Atlas (TCGA) pan-cancer dataset represen...

Hui-Juan Yi, Yan Wang, Chen-Hao Zhao et al. · BMC Medical Genomics · 0 citations

Open access Sep 2026

Arhgap25 Promotes Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) by Driving Kupffer Cell Polarization via Activation of the AKT/mTOR Signaling Pathway.

BACKGROUND Metabolic dysfunction-associated steatotic liver disease (MASLD) is a leading global health burden, yet the regulatory nodes linking hepatic immune dysregulation to metabolic perturbations remain incompletely understood. METHODS We integrated bulk and single-cell RNA sequencing (scRNA-seq) to identify core...

Yan Wang, Shuang-Shuang Lu · Frontiers in Bioscience · 0 citations