Author

Yan Wang

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Open access Sep 2026

Vibrio vulnificus hemolysin drives NLRP3 inflammasome activation in platelets via TRPC6-mediated calcium signaling.

Vibrio vulnificus, an opportunistic pathogenic species, predominantly induces sepsis in patients with liver disease rather than in healthy individuals, although its opportunistic pathogenic mechanisms are unclear. The role and mechanisms behind the NLRP3 inflammasome activation induced by V. vulnificus infection in nor...

Shi-Qing Li, Yan Wang, Zi-Han Feng et al. · Journal of Biological Chemis... · 0 citations

Open access Sep 2026

Dynamic orchestration of structural and immune cells in acute Pseudomonas aeruginosa pneumonia revealed by time-resolved single-cell and spatial transcriptomics

Background Pseudomonas aeruginosa pneumonia triggers a complex, dynamic host response, yet the cellular coordination of inflammation and repair remains poorly defined. Methods We performed time-resolved single-cell RNA sequencing (scRNA-seq) on murine lungs across five timepoints (0–96 h post-infection) and integrated...

Fu-Liang Zong, Yan Wang, Ling-Fei Hu et al. · Frontiers in Immunology · 0 citations

Open access Sep 2026

A Dual role of alveolar macrophage in driving host defense and pulmonary immunopathology during hypervirulent Acinetobacter baumannii pneumonia.

It is suggested that targeting AM phenotypic plasticity represented a promising therapeutic strategy to alleviate excessive immunopathology while preserving protective host defense while preserving protective host defense during hvAB pneumonia.

Duo Su, Yan Wang, Lu Li et al. · Protein & Cell · 0 citations