Background: Gastric cancer (GC) is one of the most common malignant tumors in the digestive tract, characterized by a high degree of malignancy and a poor prognosis. Complex disease heterogeneity, late diagnosis, and suboptimal treatment often lead to poor prognoses for patients. In addition to genetic alterations and...
Di-Di Yuan, Yan-Ling Li, H. Yi et al.· Cureus· 0 citations
ABSTRACT Cyclin E1 (CCNE1), a pivotal member of the cyclin family, governs the G1/S phase transition of the cell cycle by binding to and activating cyclin‐dependent kinase 2 (CDK2), thereby initiating DNA replication and driving S‐phase entry. In a broad spectrum of human malignancies—including breast, ovarian, gastric...
Li-Rui Yan, Si-Yi Liu, Yan-Ling Li et al.· Cancer Medicine· 0 citations
This review systematically examines the intricate regulatory network of cellular senescence, encompassing multiple pathways including telomere dysfunction, DNA damage response, epigenetic remodeling, hormone signaling, and metabolic reprogramming, and integrating such strategies with conventional therapies holds promis...
