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Author

Yan Liang

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2 papers indexed here

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Open access Oct 2026

Decoding super-enhancer regulatory grammar and pathogenic gain-of-function variants directly from DNA sequence

Super-enhancers (SEs) drive cell-identity gene expression, yet their identification relies on epigenomic profiling (e.g., H3K27ac ChIP-seq), precluding discovery in unprofiled cellular states and leaving their underlying sequence grammar unknown. Here, we present Borzoi-SE, a deep learning framework built upon the geno...

Yan Liang, Xiao-Hui Xu, Yi-Ping Mao et al. · 0 citations
Open access Oct 2026

Deciphering the Molecular and Cellular Landscape of Early Diabetic Nephropathy through Single-Cell RNA Sequencing and Protein-Protein Interaction Networks.

Diabetic nephropathy (DN) arises through complex pathological mechanisms that remain incompletely understood. This study employs transcriptomic and single-cell RNA sequencing (scRNA-seq) approaches to systematically characterize gene expression patterns, cellular composition changes, and intercellular communication net...

Li Qin, Yan Liang, Li-Ying Xuan et al. · 0 citations

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