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Author

Yan Liang

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2 papers indexed here

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Open access Sep 2026

Shewanella oneidensis employs both β-lactam resistance and tolerance controlled by the PghKR system

ABSTRACT Antibiotic tolerance enables bacterial survival during antibiotic exposure and can promote the evolution of resistance, thereby threatening therapeutic efficacy. However, the molecular mechanisms underlying tolerance and its relationship with resistance remain incompletely understood. In this study, we show th...

Jing-Xiao Cai, Yan Liang, Yu Chen et al. · 0 citations
Sep 2026

CDK4/6 Inhibitor Abemaciclib Arrests and Reverses Kidney Cyst Progression in Preclinical Models of Autosomal Dominant Polycystic Kidney Disease.

Abemaciclib has greater therapeutic efficacy and tolerability than tolvaptan in this preclinical model, largely driven by CDK6 inhibition-mediated restoration of axonemal polyglutamylation and increased ciliary polycystin abundance.

Ying-Shu Cao, Xiao-Bo Sun, Yan Huang et al. · 0 citations

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