Single-cell transcriptomic analysis reveals systemic immune dysregulation and identifies PLEK as a candidate hub gene associated with CD8+ T-cell activation in myasthenia gravis.
This study provides a systems-level view of immune dysregulation in MG, highlighting enhanced intercellular communication, T-cell dysregulation, and PLEK as a potential molecular marker associated with CD8+ T-cell activation and disease severity, offering insights into MG pathogenesis and therapeutic targets.