Yan Gao

Digital Nanopore Counting Enabling Direct Identification of Trace-Level Neoantigens in Native Biological Samples

Tumor-specific neoantigens have been the most promising targets for TCR-based cancer therapies; however, their detection is greatly hindered by low abundance, sequence variability, and potential modifications. To address these, we developed a digital nanopore framework to unambiguously identify and effectively quanti...