Chemoresistance and dose-limiting toxicity remain major challenges in cancer chemotherapy, largely driven by aberrant activation of the protein kinase B (AKT) survival pathway. Although small-molecule AKT inhibitors can enhance chemosensitivity, their systemic activity frequently disrupts normal metabolic processes and...
Qi Fang, Xiao-Jun Zhang, Chong-Bo Ma et al.· ACS Nano· 0 citations
Diabetic retinopathy (DR) is a major microvascular complication of diabetes, yet accessible molecular tools for early-stage screening remain limited. Circulating microRNAs are promising non-invasive biomarkers for DR, but their reliable quantification in serum is hindered by low abundance, matrix interference, and limi...
Tian-Shi Yang, Zi-Lin Tian, Zhao-Wei Guan et al.· Talanta: The International J...· 0 citations
A crosslinker-free photodynamic hydrogel platform based on a physically assembled poly(vinyl alcohol) (PVA) network incorporating a water-soluble cyclometalated Ir(III) photosensitizer in its sodium salt form (IrONa) offering an antibiotic-free platform for infected wound treatment.
Tian Luan, Yu Zhang, Weijin Zhu et al.· Journal of materials chemist...· 0 citations
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