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Author

Yajun Duan

2 papers indexed here

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Open access Aug 2026

Hepatic ChREBP Drives Cardiac Remodeling via ApoM Non-transcriptional Repression

This work identifies the hepatic ChREBP-SURF4-ApoM axis as a critical pathway in cardiac remodeling, and induction of hepatic ApoM secretion constitutes a new promising approach for treating cardiac remodeling and heart failure.

Shuang Zhang, Zhen-zhen Zhang, Zi-Han Ma et al. · 0 citations
Open access Jul 2026

ACSS2-KAT5 complex-driven histone crotonylation orchestrates a pro-inflammatory program to promote the transition from MASLD to MASH

A previously unrecognized role for hepatic acetyl-CoA synthetase short-chain family member 2 (ACSS2) in MASH is demonstrated, showing that ACSS2 upregulation in patients exacerbates MASH progression by functioning as an epigenetic regulator, independent of its canonical lipogenic role.

Xiao Wen, Ke Wu, Mengyao Wang et al. · 0 citations

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