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Author

Ya-Zhou Huang

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Case report Open access Oct 2026

Identification of Variants in Two Families With Congenital Cataract by Whole Exome Sequencing

ABSTRACT Background Congenital cataract (CC) is an ophthalmic disorder diagnosed at birth or during early infancy, characterized by severe visual impairment and potential blindness. This study aimed to evaluate the pathogenicity of two variants: GJA8 c.201C>G (p.Asp67Glu) and CRYBB2 c.325A>T (p.Ile109Phe). Methods The...

Ya-Zhou Huang, Xin-Wei Leng, Ji-Bo Zhang et al. · 0 citations
Review Open access Jul 2026

Strategies and mechanisms of precision genome engineering: From gene editing to genome writing

Genomic manipulation has advanced from stochastic nuclease‐mediated disruption toward programmable, deterministic precision. Early clustered regularly interspaced short palindromic repeats (CRISPR) strategies enabled targeted mutagenesis through double‐strand breaks; however, their therapeutic application is limited by...

Ke-Rui Huang, Jianhong Tian, Wen-Yan Zhao et al. · 3 citations

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