Ya-Ze Li

Discovery of 3-Carboxyl-4-pyrazolamides as Promising Herbicidal Scaffolds Targeting Dihydroorotate Dehydrogenase

Enhancing innovation in herbicide discovery is imperative to combat weed resistance and safeguard global food security. To develop novel herbicide targeting dihydroorotate dehydrogenase (DHODH), a series of 3-carboxy-4-pyrazole amide lead scaffold bearing ester or acid substituents were designed and synthesized. Bioa...