Author

Ya-Xin Zhou

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Open access Oct 2026

Citronellol Potentiates Antibiotics Against Escherichia coli O157:H7 via Inhibition of Biofilm Formation

The rise in antimicrobial resistance (AMR) demands new treatments, especially for biofilm-associated infections where bacteria tolerate antibiotics. Escherichia coli O157:H7 (E. coli O157) is a virulent foodborne pathogen that causes severe haemorrhagic colitis and haemolytic uraemic syndrome. The LuxS/AI-2 quorum sens...

Hong-Xing Zhang, Jing Xu, Wen-Kui Bao et al. · Biomolecules · 0 citations

Open access Oct 2026

4-Hydroxycoumarin inhibits biofilm formation and enhances antibiotic efficacy against Escherichia coli O157:H7

Conventional bactericidal antibiotics often fail to eradicate Escherichia coli O157:H7 ( E. coli O157) infections due to biofilm-mediated antimicrobial tolerance, and monotherapy can inadvertently drive resistance selection. This study aimed to identify compounds capable of modulating LuxS/AI-2-related phenotyp...

Hong-Xing Zhang, Jing Xu, Ya-Xin Zhou et al. · Frontiers in Microbiology · 0 citations

Open access Sep 2026

Naturally Occurring 2-Methoxy-1,4-naphthoquinone Attenuates Biofilm Formation and Quorum Sensing-Regulated Virulence in Pseudomonas aeruginosa

Pseudomonas aeruginosa employs quorum sensing (QS) to coordinate biofilm formation and virulence factor expression, positioning QS as a promising target for anti-infective interventions. This study evaluated the antibiofilm and antivirulence efficacy of 2-methoxy-1,4-naphthoquinone (MNQ), a natural naphthoquinone, agai...

Rong-Jia Han, Yu-Ting Bai, Ya-Xin Zhou et al. · Biomolecules · 0 citations