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Sponsored AI Networking Cookbook: Practical recipes for AI-assisted network automation and development AI Networking Cookbook: Practical recipes for AI-assisted network automation and development

Author

Ya-Ping Rong

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Oct 2026

Development of DCL1191 as a Potent, Selective and Orally Bioavailable Inhibitor for Autophagy-Associated Transcription Factor EB (TFEB).

Transcription factor EB (TFEB) is a promising target for autophagy regulation and cancer therapy, yet it has long been regarded as an undruggable protein. Starting from eltrombopag, an FDA-approved agent that exhibits both thrombopoietin receptor (Tpo-R) agonistic activity and TFEB inhibitory potency, we performed syst...

Chang-Le Du, Ya-Ping Rong, Zi-Lu Wang et al. · 0 citations
Oct 2026

A Substrate-Permissive Vanadium Haloperoxidase in Type II Polyketide Biosynthesis Unlocks Non-Native Halogenation across Diverse Substrate Scaffolds.

Halogenated compounds are prevalent in natural and synthetic molecules, profoundly affecting molecular stability, physicochemical properties, and biological activity. While enzymatic halogenation offers a sustainable and selective synthetic route, its broad application is limited by the narrow substrate scope of the kn...

S.-Q. Fang, D. Ding, Qiu-Yue Nie et al. · 0 citations

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