Author

Ya-Pin Shi

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Open access Sep 2026

InstructPLM-mu: protein fitness prediction from structure instructions

Abstract Multimodal protein language models (PLMs) deliver strong performance on mutation-effect prediction, but training such models from scratch demands substantial computational resources. In this paper, we propose a fine-tuning framework called InstructPLM-mu and investigate the question: Can a pretrained sequence-...

Jun-De Xu, Ya-Pin Shi, Li-Jun Lang et al. · Briefings in Bioinformatics · 0 citations