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Ya-Nan Yan

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Review Open access Oct 2026

Single-cell and spatial transcriptomics in intrahepatic cholangiocarcinoma: spatial immune ecosystems, metabolic remodeling, and immunotherapeutic implications

Intrahepatic cholangiocarcinoma (iCCA) is an aggressive liver malignancy characterized by pronounced cellular, spatial, and metabolic heterogeneity. Single-cell RNA sequencing (scRNA-seq) and spatial transcriptomics (ST) are beginning to resolve this complexity by linking malignant, immune, stromal, and metabolic state...

Ya-Nan Yan, Tian-Hao Teng, Xin-Ying Luo et al. · 0 citations

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