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Open access Oct 2026

Discovery and Optimization of the Novel Immunotoxins Targeting TROP2 for Cancer Therapy

Background: Trophoblast cell surface antigen 2 (TROP2) is widely overexpressed in epithelial cancers and associated with poor prognosis, representing an attractive target for cancer treatment. Recent clinical studies reported favorable outcomes of TROP2-targeting antibody–drug conjugates. However, heterogeneity of huma...

Jun-Yan Li, Tanja Poredoš, Shu-Yi Xu et al. · 0 citations

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