Author

Ya-Kun Liu

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Open access Sep 2026

Matrine Suppresses Lung Cancer Progression via Dual Inhibition of CHEK1‐Mediated DNA Damage Repair and PI3K/AKT Survival Signaling

Lung cancer remains a leading cause of cancer‐related mortality worldwide, necessitating the development of novel therapeutic strategies. Matrine, a natural alkaloid derived from Sophora flavescens, has demonstrated broad antitumor properties, yet its underlying mechanisms, particularly concerning DNA damage response,...

Jiang-Hao Yu, Si-Yang Chen, Ting-Ting Hou et al. · Thoracic Cancer · 0 citations

Open access Sep 2026

Integrative Transcriptomic and Genetic Analysis Nominally Prioritizes SLC51A and TPMT as Candidate Diagnostic Genes for Thoracic Aortic Aneurysm

This study identifies SLC51A and TPMT as candidate diagnostic genes for TAA and proposes a simple two‑gene nomogram, which indicates that variation in SLC51A and TPMT expression is associated with coordinated changes in RNA metabolism, macromolecular catabolism, energy utilization, and cell‑cycle–related processes.

Jun-Chao Huang, Jin-Shan Zhou, Ya-Kun Liu et al. · Artery Research · 0 citations

Sep 2026

A rare germline TXNIP missense mutation may contribute to the genesis of Familial ovarian mature teratoma in human.

Findings establish TXNIP as the first functional candidate susceptibility gene for this phenotype and connect inherited susceptibility to ubiquitin-dependent protein turnover, GLUT1-driven metabolic reprogramming, and PI3K/mTOR-dominant follicular signaling.

Ya-Nan Zhang, Yan Li, Ya-Kun Liu et al. · Molecular and Cellular Endoc... · 0 citations