Spatial transcriptomics (STs) have become a valuable approach for understanding the growth and development of organisms. Despite the recent emergence of numerous ST models, accurately identifying spatial domains remains challenging owing to the trade-off between preserving local details and reducing noise. Here, we int...
Drug repositioning offers an efficient alternative to de novo drug development; however, accurately identifying potential drug-disease associations remains challenging. Existing methods do not fully exploit higher-order collaborative information at the drug-drug and disease-disease levels, and their feature fusion stra...
Hao Zhang, Jin-Can Li, Xian-Fang Tang et al.· Journal of Chemical Informat...· 0 citations
DiffPro, a novel framework that integrates a Latent Diffusion Model (LDM) as a structural prior, confirms that the diffusion prior successfully regularizes the latent space, mitigating task representation collapse and enabling robust, high-precision predictions for combination therapy design.
Shu-Ting Jin, Xu Guo, An-Qi Huang et al.· Proceedings of the 32nd ACM...· 0 citations
GoMA-DTA is proposed, a framework integrating gene ontology (GO) functional annotations with protein semantic features with channelwise gating mechanism that uses functional semantics as anchors to dynamically recalibrate ESM-2embeddings, achieving adaptive semantic filtering.
An Xiong, Zheyu Zhou, Ya-Zi Li et al.· IEEE Transactions on Neural...· 0 citations
MultiGeo is a DTA prediction framework that explicitly leverages multiple protein conformations rather than a single snapshot, and introduces a disagreement-aware gating mechanism that adaptively fuses this ensemble representation with the dominant structure only when the additional conformers provide complementary inf...
Rui-Da Zeng, Cheng Guo, Ya-Jie Meng et al.· Proceedings of the Thirty-Fi...· 0 citations
Accurate prediction of drug-target binding affinity (DTA) is a key task in virtual screening. However, current computational methods face a key challenge: sequence-based approaches often fail to capture critical spatial information, while structure-based models rely on computationally expensive 3D coordinates, which re...
Junlin Xu, Ye Yuan, Menglong Hu et al.· IEEE journal of biomedical a...· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.
