Author

Ya-Dong Yuan

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Open access Oct 2026

Integrated multi-omics and machine learning identify core mechanobiology-associated immune genes in pulmonary arterial hypertension

Pulmonary arterial hypertension (PAH) involves vascular remodeling and altered mechanical signaling. The immune-associated transcriptomic changes accompanying this environment remain incompletely characterized. We integrated bulk lung (GSE15197), PBMC (GSE33463), and single-cell RNA-seq (GSE169471) data usin...

Pei Wang, Fan Zhao, Ting Yang et al. · Frontiers in Immunology · 0 citations

Sep 2026

Sinapine thiocyanate (ST) ameliorates endothelial cell dysfunction by targeting chloride intracellular channel 4 (CLIC4) to treat hypoxia-induced pulmonary hypertension.

BACKGROUND AND PURPOSE Sinapine thiocyanate (ST) has effects in treating respiratory diseases. Its action in hypoxic pulmonary hypertension (HPH) remains poorly understood. We evaluated the potential of ST on HPH and its molecular mechanism. EXPERIMENTAL APPROACH ST was evaluated on a rat model HPH. Single-cell RNA s...

X. Gong, Yu-Ming Wang, Shi-Wei Kang et al. · British Journal of Pharmacol... · 0 citations