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Y. Zhuo

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Open access Aug 2026

Spatial multi‐omics unveils sphingolipid metabolic reprogramming within the retinal pathological niche

It is revealed that spatially defined immunometabolic remodeling—in which Trem2 + microglia are central—converges on sphingolipid metabolism as a druggable regulatory axis, with the TREM2‐SPTLC2 interface thus emerging as a new therapeutic opportunity for retinal neurodegenerative diseases.

Yun-Hong Shi, Jinpei Lin, Yi Wu et al. · 0 citations

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